Immunological and virological features of combined secondary diseases in patients with HIV-based immunodeficiency

Introduction. The HIV epidemic situation in the Russian Federation remains tense. Low coverage of antiretroviral therapy (ART) contributes to disease progression some PLHIV. Many authors point a high prevalence different secondary combinations. Objective. Studying structure combinations inpatients and identifying features immunological virological indicators. Materials methods. There was retrospective analysis 1440 cases HIV-infected admission ICU SBHI «ICH № 2» DZM 2018–2020. number CD4+ cells were estimated 1185 patients, viral load (VL) is defined 1173 patients. Statistical held, using program StatTech v. 2.6.2 (developer — LLC «Statech», Russia). Results. 18,5% patients had 1 disease, 75,9% diagnosed combination 2 more various lesions. 275 diseases are recorded: from 50 lesions 4 7 nosological units. Ме VL with no 13 303 copies/ml, it increased 3,2 times (42 926) (p<0,001). Similar changes detected 3, 5 6 diseases. lymphosytes absence pathology 223 cells/mcl. As increases 4, we observe consistent reduction lymphosytes; combined did not exceed 100 cells; this figure 20 mcl. Correlation revealed presence moderate connection tightness on Chaddock scale (r xy =0,356, p<0,001). depth immunodeficiency also affects outcome disease: (M±SD) group dead 101±153 (95% DI: 91–112), survivors 198±226 DI:172–224; Conclusion. Combined among infectious hospital 75.9% differences by level which growth lesion number; significant correlation found between amount obtained results confirmed reduced likelihood favorable increasing